A pair of papers from researchers at the Washington University School of Medicine in St. Louis are among those chosen as the best papers published by The Journal of Biological Chemistry during 2014.
“An Immunogenic Peptide in the A-box of HMGB1 Protein Reverses Apoptosis-induced Tolerance Through RAGE Receptor” from Thomas A. Ferguson, PhD, professor of ophthalmology and visual sciences, and colleagues, was honored for identifying an immune mechanism that may have therapeutic implications in inflammatory and infectious diseases.
“A Mechanism Regulating G protein-coupled Receptor Signaling that Requires Cycles of Protein Palmitoylation and Depalmitoylation” from Kendall Blumer, PhD, professor of cell biology and physiology, and colleagues, was recognized for identifying a way to enhance the activity of an important nerve cell channel, an advance that could help treat some neurological disorders.