Gut microbes’ metabolite dampens proliferation of intestinal stem cells

Gut microbes’ metabolite dampens proliferation of intestinal stem cells

New research at Washington University School of Medicine in St. Louis indicates stem cells located in “pockets” in the intestine avoid contact with a prominent metabolite produced by beneficial microbes living in the gut. That metabolite – butyrate – restricts the proliferation of stem cells, potentially hampering the intestine from repairing itself after an injury or damage.
Development of gut microbes and gut immunity linked

Development of gut microbes and gut immunity linked

Studying twins from birth through age 2, scientists at Washington University School of Medicine in St. Louis have shown that the gut’s immune system develops in sync with the gut’s tens of trillions of microbes. The findings have implications for understanding healthy growth and, potentially, the origins of various immune disorders.
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