Barnes’ laboratory applies improvements in magnetic resonance spectroscopy to biomolecular structure determination. Solid state nuclear magnetic resonance (NMR) is exquisitely suited to probe atomic level structural detail of biomolecules not amendable to x-ray crystallography.
Researchers from the School of Medicine have found that the immune system may be triggered to treat atherosclerosis and possibly other metabolic conditions, including fatty liver disease and type 2 diabetes.
Washington University’s Alexander Barnes, a chemist, physicist, electrical engineer and molecular biologist rolled into one, just received a $2.3 million grant from the National Institutes of Health to develop a nuclear magnetic resonance spectrometer that can determine the structure of molecules very quickly and at room temperature. His first target is a drug called bryostatin that may flush out HIV hidden in the chromosomes of our own cells.