Collaboration lets researchers ‘read’ proteins for new properties
A collaboration between the McKelvey School of Engineering and St. Jude Children’s Research Hospital uncovers the underlying rules that, when broken, contribute to neurodegenerative diseases such as ALS.
Drug compound halts Alzheimer’s-related damage in mice
Researchers at the School of Medicine have shown that levels of tau protein can be reduced – and some of the neurological damage caused by tau even reversed – by a synthetic molecule that targets genetic instructions. The findings are important for Alzheimer’s and other neurological diseases.
Obituary: Jason S. Goldfeder, assistant professor of medicine, 45
Jason S. Goldfeder, MD, a revered teacher in the Division of Medical Education of the Department of Medicine at the School of Medicine, died Dec. 9, 2015, following a 12-year battle with amyotrophic lateral sclerosis (ALS).
Miller named Clayson Professor of Neurology
Timothy M. Miller, MD, PhD, a leading researcher in the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), has been named the David Clayson Professor of Neurology at the School of Medicine. The professorship was established in 2001 through a bequest from David Clayson, PhD, to support innovative research into treatments for ALS.
Genetic errors linked to more ALS cases than scientists had thought
Genetic mutations may cause more cases of amyotrophic
lateral sclerosis (ALS) than scientists previously had realized, according
to researchers. Shown are study authors Janet Cady, a PhD candidate, and Matthew Harms, MD, assistant professor of neurology at the School of Medicine.
Heart drug may help treat ALS, mouse study shows
Digoxin, a medication that has been used to treat heart
failure, may be adaptable for the treatment of amyotrophic lateral sclerosis
(ALS), a progressive, paralyzing disease, suggests new research at
the School of Medicine.
Obituary: Thomas H. Steinberg, MD, associate professor of medicine, 61
Thomas H. Steinberg, MD, associate professor of medicine, died Sunday, June 16, 2013, in St. Louis of complications from amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig’s Disease.
ALS trial shows novel therapy is safe
An investigational treatment for an inherited form of
Lou Gehrig’s disease has passed an early phase clinical trial for
safety, researchers at the School of Medicine and Massachusetts General Hospital report. A mutated protein that causes an inherited form of Lou
Gehrig’s disease leads to clumps in the human cells, which are pictured.
Goate appointed director of Hope Center for Neurological Disorders
Alison Goate, PhD, has been named director of the Hope Center for Neurological Disorders, a partnership between Washington University School of Medicine in St. Louis and Hope Happens, a nonprofit foundation that supports research into neurodegenerative disorders.