Alzheimer’s disease

Meredith Jackrel, assistant professor of chemistry in Arts & Sciences, recently received a five-year grant from the National Institutes of Health (NIH) and another from the Longer Life Foundation to study protein disaggregases —  evolved protein forms that mitigate protein misfolding — as a strategy to combat neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS.

An engineer at Washington University in St. Louis plans to push the envelope of microscopic imaging, to better visualize the molecules involved in Alzheimer’s disease.  

As Alzheimer’s disease and other forms of dementia continue to become more prevalent, it may not be long before there is a push for legalizing physician-assisted death in dementia cases in the United States. American officials must thoroughly consider the moral and social consequences of such an action, says an expert on medical ethics at Washington University in St. Louis.

New research from Washington University in St. Louis shows that the protein behind Alzheimer’s disease shape-shifts, changing its internal structure in order to infiltrate brain cells and become toxic.

Long before Alzheimer’s disease can be diagnosed clinically, increasing difficulties building cognitive maps of new surroundings may herald the eventual clinical onset of the disorder, finds new research from Washington University in St. Louis.

A chemist at Washington University in St. Louis hopes to develop bifunctional compounds that can be both therapeutic and diagnostic agents for Alzheimer’s disease. In the first role, they would block the metal-mediated formation of amyloid beta oligomers; in the second, they would be loaded with a long-lived radioistope (Cu-64) and employed as PET imaging agents.

Studying mice and tissue samples from the arteries of patients with atherosclerosis, researchers at Washington University School of Medicine in St. Louis suggest this plaque accumulation is driven, at least in part, by processes similar to the plaque formation implicated in brain diseases such Alzheimer’s and Parkinson’s.

Many studies have linked more sleep to better memory, but new research in fruit flies at Washington University School of Medicine in St. Louis demonstrates that extra sleep helps the brain overcome catastrophic neurological defects that otherwise would block memory formation.

Highlighting a potential target in the treatment of multiple sclerosis (MS) and Alzheimer’s disease, new research suggests that triggering a protein found on the surface of brain cells may help slow the progression of these and other neurological diseases.

Two major Alzheimer’s disease studies at Washington University School of Medicine in St. Louis have received federal funding totaling $30 million over the next five years.