Engineering proteins to help counter devastating diseases

Engineering proteins to help counter devastating diseases

Meredith Jackrel, assistant professor of chemistry in Arts & Sciences, recently received a five-year grant from the National Institutes of Health (NIH) and another from the Longer Life Foundation to study protein disaggregases —  evolved protein forms that mitigate protein misfolding — as a strategy to combat neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS.
WashU Expert: Physician assisted death for Alzheimer’s, dementia?

WashU Expert: Physician assisted death for Alzheimer’s, dementia?

As Alzheimer’s disease and other forms of dementia continue to become more prevalent, it may not be long before there is a push for legalizing physician-assisted death in dementia cases in the United States. American officials must thoroughly consider the moral and social consequences of such an action, says an expert on medical ethics at Washington University in St. Louis.
Longer-lived imaging agents could hasten Alzheimer’s research

Longer-lived imaging agents could hasten Alzheimer’s research

A chemist at Washington University in St. Louis hopes to develop bifunctional compounds that can be both therapeutic and diagnostic agents for Alzheimer’s disease. In the first role, they would block the metal-mediated formation of amyloid beta oligomers; in the second, they would be loaded with a long-lived radioistope (Cu-64) and employed as PET imaging agents.
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