arthritis

Using new gene-editing technology, researchers at the School of Medicine have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic conditions.

Combining a drug for rheumatoid arthritis with one that targets the chikungunya virus can eliminate the signs of chikungunya arthritis in mice in the disease’s earliest stage, according to researchers at Washington University School of Medicine in St. Louis.

Enzymes linked to diabetes and obesity appear to play key roles in arthritis and leukemia, potentially opening up new avenues for treating these diverse diseases, according to researchers Clay Semenkovich, MD, (left) and Irfan Lodhi, PhD, at the School of Medicine.

New research from Washington University School of Medicine in St. Louis shows that the same genes that promote healing after cartilage damage also appear to protect against osteoarthritis, a condition caused by years of wear-and-tear on the cartilage between joints. Although the research was conducted in mice, the genes are likely to be important in people, too.

Surgeons and rehabilitation specialists concentrate on the anatomical and mechanical aspects, but Linda Sandell, PhD, looks at the biology behind arthritis, broken bones and cartilage tears.The Mildred B. Simon Professor and director of research in the Department of Orthopaedic Surgery says there are a number of opportunities to apply biology to orthopaedic problems.  

Pitchers often lose range of motion in their pitching elbows.Now that the Chicago White Sox have swept the Houston Astros in the World Series, most baseball players are taking some time to rest. Time off is especially important for pitchers because throwing a baseball overhand is both an unnatural motion and a burden on the shoulder and elbow. Now a research team led by Washington University sports medicine specialists has found that professional pitchers have significantly decreased range of motion in their throwing elbows.

Pitchers often lose range of motion in their pitching elbows.Now that the Chicago White Sox have swept the Houston Astros in the World Series, most baseball players are taking some time to rest. Time off is especially important for pitchers because throwing a baseball overhand is both an unnatural motion and a burden on the shoulder and elbow. Now a research team led by Washington University sports medicine specialists has found that professional pitchers have significantly decreased range of motion in their throwing elbows. But that limited range of motion doesn’t seem to be influenced by the age of the pitcher, how many innings he has pitched or whether he has a history of injuries.

Arthritis can hit harder in African- Americans.A pilot study comparing the results of treatment for rheumatoid arthritis in African-Americans and Caucasians has revealed that African-Americans are more likely to suffer pain and disability from the disorder. Researchers at the School of Medicine found that both disease activity and the resulting disabilities were worse in African-Americans. Further analysis showed this was linked primarily to socio-economic status rather than race.

Arthritis can hit harder in African-Americans.A pilot study comparing the results of treatment for rheumatoid arthritis in African-Americans and Caucasians has revealed that African-Americans are more likely to suffer pain and disability from the disorder. Researchers at Washington University School of Medicine in St. Louis studied a group of 33 African-Americans and 67 Caucasians and found that both disease activity and the resulting disabilities were worse in African-Americans. Further analysis showed this was linked primarily to socio-economic status rather than race.