Persistent childhood asthma sets stage for COPD

Persistent childhood asthma sets stage for COPD

Children with mild to moderate persistent asthma are at greater risk of developing chronic lung disease as young adults and, therefore, may require lifelong treatment even if their asthma symptoms subside for extended periods, according to a major national study co-led by researchers at the School of Medicine.

Finding points to a cause of chronic lung disease

Scientists have long suspected that respiratory viruses play a critical role in the development of chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). Studying mouse and cell models of this process, researchers now have shown how immune cells dispatched to the lung to destroy a respiratory virus can fail to disperse after their job is done, setting off a chain of inflammatory events that leads to long-term lung problems.

Study sheds new light on asthma, COPD

In cells lining the airway, high levels of certain proteins have long been linked with the overproduction of mucus characteristic of diseases like asthma and COPD. New research from the School of Medicine provides clues to potentially counteract inappropriate mucus production.

Investigational drug can reduce asthma flareups

An investigational drug appears to cut the risk of severe asthma attacks in half for patients who have difficulty controlling the disorder with standard medications, according to results from two multicenter clinical trials headed by Mario Castro, MD, the Alan A. and Edith L. Wolff Professor of Pulmonary and Critical Care Medicine at the School of Medicine.

Treatment strategy may reduce infants’ wheezing caused by virus

The antibiotic azithromycin may reduce the risk of recurrent wheezing in infants hospitalized with a common respiratory infection, according to a small pilot study at the School of Medicine. Reduced wheezing may lower an infant’s risk of developing asthma over the next several years, according to the researchers, including first author Avraham Beigelman, MD.
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