The greatest risk factor for Alzheimer’s disease is advancing age. Researchers at Washington University School of Medicine in St. Louis have identified some of the key changes in the aging brain that lead to the increased risk. The changes center on amyloid beta 42, a main ingredient of Alzheimer’s brain plaques.
Randall J. Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology at the School of Medicine, has received a MetLife Foundation Award for Medical Research. Bateman, a leader in Alzheimer’s disease research, is the university’s fifth researcher to receive the prize.
U.S. Sen. Roy Blunt, R-Mo., visited the Medical Campus this week to meet with physicians who treat patients with Alzheimer’s disease, and patients and caregivers who live with the debilitating disease every day. Blunt, pictured with physician-scientist Randall J. Bateman, chairs a subcommittee that oversees funding for medical research.
David M. Holtzman, MD, and Randall J. Bateman, MD, have been chosen as co-recipients of the Chancellor’s Award for Innovation and Entrepreneurship at Washington University in St. Louis.
Leading scientists have selected the first drugs to be evaluated in a worldwide clinical trial to determine whether they can prevent Alzheimer’s disease. The pioneering trial, expected to start by early 2013, initially will test three promising drugs, each designed to target Alzheimer’s in different ways.
Scientists have assembled the most detailed chronology to date of the human brain’s long, slow slide into full-blown Alzheimer’s disease. Through an international research partnership known as the Dominantly Inherited Alzheimer’s Network (DIAN), scientists at Washington University and elsewhere evaluated pre-symptomatic markers of Alzheimer’s disease in subjects from families genetically predisposed to develop the disorder.
A marker for Alzheimer’s disease rises and falls in the spinal fluid in a daily pattern that echoes the sleep cycle, researchers at Washington University School of Medicine in St. Louis have found. The pattern is strongest in healthy young people and reinforces a link between increased Alzheimer’s risk and inadequate sleep that had been discovered in animal models.
Neurologists finally have an answer to one of the most important questions about Alzheimer’s disease: Do rising brain levels of a plaque-forming substance mean patients are making more of it or that they can no longer clear it from their brains as effectively? A new study by Randall Bateman, MD, assistant professor of neurology, shows clearance is impaired in Alzheimer’s patients.