Washington People: Angela L. Brown

Angela L. Brown, MD, associate professor of medicine, leads the Hypertension Clinic at Washington University School of Medicine. Brown has devoted her career to helping patients control their hypertension and to training medical professionals in how to care for such patients.

Diabetes drug may reduce heart attack risk in HIV patients

A diabetes drug may have benefits beyond lower blood sugar in patients with HIV. New research from the laboratory of Kevin E. Yarasheski, PhD, suggests the drug may prevent cardiovascular problems because it works to reduce inflammation that is linked to heart disease and stroke in these patients. The drug both improved metabolism and reduced inflammation in HIV-positive adults on antiretroviral therapy.

Study: Most respond well to genetic testing results

People at high risk for psychological distress respond positively to receiving results of personalized genetic testing, according to new research at Washington University School of Medicine in St. Louis. More than 60 percent of subjects in the genetic study wanted information about their test results, and 95 percent said they appreciated receiving the information, regardless of whether the results were good or bad news.

$8 million to study gene-lifestyle interactions on heart health

School of Medicine researchers have received an $8 million grant to investigate the genetic and environmental roots of cardiovascular disease risk factors. The four-year grant will support the first large-scale, multiethnic statistical analysis of risk factors for cardiovascular disease that looks at lifestyle interactions with genes. Shown are principal investigators D.C. Rao, PhD, and Ingrid Borecki, PhD.

Smoking may dull obese women’s ability to taste fat and sugar

People who smoke also tend to eat more high-fat foods. So do obese people. Now, a team of researchers, including M. Yanina Pepino, PhD, at the School of Medicine, has found that obese women who also smoke have a difficult time perceiving fat and sweetness in their food. And that could lead them to eat even more fatty foods.

Well-controlled HIV doesn’t affect heart metabolism, function

People with HIV often develop blood sugar and lipid problems and other metabolic complications that increase heart disease risk. New research at Washington University School of Medicine in St. Louis shows that the HIV virus and the drugs used to treat it don’t worsen heart metabolism and function in these patients. p, , {margin:0in;margin-bottom:.0001pt;font-size:12.0pt;font-family:Cambria;} div.WordSection1 {page:WordSection1;}

Inhibiting fatty acids in immune cells decreases atherosclerosis risk

Scientists at Washington University School of Medicine in St. Louis have found a way to significantly reduce atherosclerosis in mice that does not involve lowering cholesterol levels or eliminating other obesity-related problems. Atherosclerosis is the process through which fatty substances, such as cholesterol and cellular waste products accumulate in the lining of arteries. The research team inhibited atherosclerosis in the mice by interfering with production of a substance called fatty acid synthase, an enzyme that converts dietary sugars into fatty acids in the liver.  
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