New insights into wound healing
Research from a multidisciplinary team led by Washington University in St. Louis may provide new insights into wound healing, fibrosis and cancer metastasis.
The importance of collagen fibers in health
Engineers from the McKelvey School of Engineering at Washington University have shown that the length of collagen fibers has a role to play in the ability of normal cells to become invasive.
Mouse study shows potential for gene therapy in Alport syndrome, an inherited kidney disease
A new study in mice suggests that gene therapy may one day be a viable treatment for Alport syndrome, an inherited disease that leads to kidney failure.
Discovery helps show how breast cancer spreads
School of Medicine researchers have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread. The finding opens the door to drug treatments that prevent metastasis. Shown are collagen fibers at the boundary of a tumor. Fibers that tend to be perpendicular to the tumor’s surface indicate a poor prognosis.
Cigarette smoking impedes tendon-to-bone healing
Copyright The Journal of Bone and Joint Surgery. Used with permission.Increased cell proliferation in the saline solution group (B) compared to the nicotine group (A)Orthopaedic surgery researchers at the School of Medicine have identified yet another reason not to smoke. Studying rotator cuff injury in rats, the research team found exposure to nicotine delays tendon-to-bone healing, suggesting this could cause failure of rotator cuff repair following surgery in human patients. This study, the first to evaluate the effects of nicotine on rotator cuff repair, found that inflammation persisted longer in the shoulder joints of rats exposed to nicotine. The researchers also noted less cellular proliferation and decreased collagen production, indications of poor healing.
Cigarette smoking impedes tendon-to-bone healing
Copyright The Journal of Bone and Joint Surgery. Used with permission.Increased cell proliferation in the saline solution group (B) compared to the nicotine group (A)Orthopaedic surgery researchers at Washington University School of Medicine in St. Louis have identified yet another reason not to smoke. Studying rotator cuff injury in rats, the research team found exposure to nicotine delays tendon-to-bone healing, suggesting this could cause failure of rotator cuff repair following surgery in human patients. This study, the first to evaluate the effects of nicotine on rotator cuff repair, found that inflammation persisted longer in the shoulder joints of rats exposed to nicotine. The researchers also noted less cellular proliferation and decreased collagen production, indications of poor healing. More…