coronary artery disease

Rare mutations that shut down a single gene are linked to lower cholesterol levels and a 50 percent reduction in the risk of heart attack, according to new research led by Nathan Stitziel, MD, PhD, of the School of Medicine. The gene, called NPC1L1, is of interest because it is the target of the drug ezetimibe, often prescribed to lower cholesterol.

Researchers have identified the first genetic variant associated with severity of coronary artery disease in patients with type 2 diabetes. Though this variant is not likely the cause of more severe coronary disease, the researchers say, it implicates a gene that could be. Such a gene has promise as a future target for treating coronary artery disease in diabetic patients.

Abnormal heart rate variability increases the risk of death for depressed heart patients.Scientists have known for years that depression increases the risk of dying in the months after a heart attack, but they haven’t understood how depression raises that risk. Now, behavioral medicine specialists at the School of Medicine are reporting in the Archives of Internal Medicine that abnormal heart rate variability is partially responsible for depression’s effects in heart patients.

Abnormal heart rate variability increases the risk of death for depressed heart patients.Scientists have known for years that depression increases the risk of dying in the months after a heart attack, but they haven’t understood how depression raises that risk. Now, behavioral medicine specialists at Washington University School of Medicine in St. Louis are reporting in the Archives of Internal Medicine that abnormal heart rate variability is partially responsible for depression’s effects in heart patients.