Study sheds new light on asthma, COPD

In cells lining the airway, high levels of certain proteins have long been linked with the overproduction of mucus characteristic of diseases like asthma and COPD. New research from the School of Medicine provides clues to potentially counteract inappropriate mucus production.

Newborns with respiratory distress potentially have rare genetic disease

Newborns with respiratory distress should be evaluated for primary ciliary dyskinesia, a rare genetic disease that has features similar to cystic fibrosis, says Thomas Ferkol from the School of Medicine. He reports finding that about 80 percent of patients with primary ciliary dyskinesia (PCD) have a history of newborn respiratory distress.

Newborns with respiratory distress potentially have rare genetic disease

Newborns with respiratory distress should be evaluated for primary ciliary dyskinesia, a rare genetic disease that has features similar to cystic fibrosis, says Thomas Ferkol from Washington University School of Medicine in St. Louis. He reports finding that about 80 percent of patients with primary ciliary dyskinesia (PCD) have a history of newborn respiratory distress.

Lung retransplants from living donors improve survival rate in children

Charles Huddleston performs a pediatric lung transplant.A team of researchers at the School of Medicine has found that using lobes of lungs from living donors improves the chances of short-term survival for children who require a second lung transplant. Living-donor lung retransplantation involves removing a lower lobe, or about one-third of a lung, from each of two healthy adult donors and then transplanting the lobes as replacement lungs into a child.

Lung retransplants from living donors improve survival rate in children

Charles Huddleston performs a pediatric lung transplant.A team of researchers at Washington University School of Medicine in St. Louis has found that using lobes of lungs from living donors improves the chances of short-term survival for children who require a second lung transplant. Researchers compared the outcomes of lung retransplants in 39 children, including 13 patients who had lung retransplants using lobes from living donors and 26 who received lung retransplants using whole lungs from deceased donors. Living-donor lung retransplantation involves removing a lower lobe, or about one-third of a lung, from each of two healthy adult donors and then transplanting the lobes as replacement lungs into a child.

Scientists use PET scans to monitor lung inflammation noninvasively

In this PET image, the arrow shows inflammation of the lungs.A noninvasive approach for assessing lung inflammation should accelerate efforts to develop drugs for inflammatory lung conditions like cystic fibrosis and pneumonia, scientists at the School of Medicine report. Researchers have used positron emission tomography (PET) scans to monitor artificially induced inflammation in the lungs of healthy volunteers. The new imaging process may help doctors monitor the conditions of patients with inflammatory lung diseases and should make it easier for investigators to test potential anti-inflammatory drugs.

Scientists use PET scans to monitor lung inflammation noninvasively

In this PET image, the arrow shows inflammation of the lungs.A noninvasive approach for assessing lung inflammation should accelerate efforts to develop drugs for inflammatory lung conditions like cystic fibrosis and pneumonia, scientists at Washington University School of Medicine in St. Louis report. Researchers have used positron emission tomography (PET) scans to monitor artificially induced inflammation in the lungs of healthy volunteers. The new imaging process may help doctors monitor the conditions of patients with inflammatory lung diseases and should make it easier for investigators to test potential anti-inflammatory drugs.