Human cells have a way of detecting and mending DNA damage caused by some common chemotherapy drugs, according to a new study from the School of Medicine. The findings could have important implications for treating cancer.
Studying zebrafish embryos, researchers at Washington University School of Medicine in St. Louis have shown that the epigenome plays a significant part in guiding development in the first 24 hours after fertilization. The research may deepen understanding of congenital defects and miscarriage.
Researchers led by Gregory A. Storch, MD, at Washington University School of Medicine in St. Louis, have sequenced the genome of enterovirus D68 sampled from patients treated at St. Louis Children’s Hospital. Nationwide, the virus has spread rapidly in recent months and caused severe respiratory illness in young children, with some patients requiring hospitalization.
Douglas Chalker, PhD, associate professor of biology in Arts & Sciences, has been awarded $170,000 from the National Science Foundation to continue work on his project, “DNA Elimination Mechanisms in Tetrahymena.”
Scientists have decoded the genome of the platyfish, a cousin of the guppy and a popular choice for home aquariums. Scientists are interested in the fish because they tend to develop melanomas along the tail and fin.
A large team of scientists has decoded the genome of a sea lamprey – one of the few ancient, jawless species of vertebrates that has survived through the modern era.
Scientific efforts to explain feeblemindedness, delinquency and racial inferiorities date to the Spanish Inquisition. And while the horrors of Nazi Germany exposed fatal flaws in science’s quest to build the master race, the ethical dilemmas posed by the science of eugenics are far from behind us, warns an anthropologist from Washington University in St. Louis.
Our bodies contain far more microbial genes than human genes. And a new study suggests that just as human DNA varies from person to person, so too does the massive collection of microbial DNA in the intestine.
Decoding the DNA of patients with advanced breast cancer has allowed scientists to identify distinct cancer “signatures” that could help predict which women are most likely to benefit from estrogen-lowering therapy, while sparing others from unnecessary treatment.
Scientists at Washington University School of Medicine in St. Louis are using powerful DNA sequencing technology not only to identify mutations at the root of a patient’s tumor – considered key to personalizing cancer treatment – but to map the genetic evolution of disease and monitor response to treatment.