Epigenome orchestrates embryonic development

Studying zebrafish embryos, researchers at Washington University School of Medicine in St. Louis have shown that the epigenome plays a significant part in guiding development in the first 24 hours after fertilization. The research may deepen understanding of congenital defects and miscarriage.

Deep genomics: Scientists probe the epigenome

A Washington University in St. Louis team is participating in the modENCODE project, a massive ongoing effort to map all the elements in model organisms that affect whether genes are silenced or expressed. The work supports the more complex ENCODE project, which is tasked to map the same elements in the human genome. While the genome is the same in every cell, each cell type expresses a different set of genes. In people, moreover, roughly 95 percent of the genome is silenced. Together the projects will “put flesh on the bones” of the Human Genome Project, says team leader Sarah C.R. Elgin.