New models of drug-resistant breast cancer point to better treatments
Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research led by Matthew J. Ellis, MD, PhD, from Washington University School of Medicine in St. Louis.
Estrogen fights urinary infection in mouse study
Estrogen levels drop dramatically in menopause, a time when the risk of urinary tract infections increases significantly. Researchers at Washington University School of Medicine in St. Louis
have found new evidence in mice that the two phenomena are connected by
more than just timing.
Caution for estrogen therapy after hysterectomy
In an editorial in the April 6 issue of the Journal of the American Medical Association, co-author Graham Colditz, MD, PhD, cautions against estrogen-only hormone therapy in women who have had a hysterectomy because of longstanding evidence that it raises the risk of breast cancer.
Estrogen-lowering drugs minimize surgery in breast cancer patients
A nationwide study has confirmed the benefit of giving estrogen-lowering drugs before surgery to breast cancer patients. The treatment increased the likelihood that women could undergo breast-conservation surgery, also called lumpectomy, instead of mastectomy.
Estrogen is important for bone health in men as well as women
DXA scans of a male patient with osteoporosisAlthough women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating – or even life-threatening – fractures. In women, low estrogen levels after menopause have been considered an important risk factor for this disorder. Now research at the School of Medicine has shown that low amounts of active estrogen metabolites also can increase the the risk of osteoporosis in men.
Estrogen is important for bone health in men as well as women
DXA scans of a male patient with osteoporosisAlthough women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating – or even life-threatening – fractures. In women, low estrogen levels after menopause have been considered an important risk factor for this disorder. Now research at Washington University School of Medicine in St. Louis has shown that low amounts of active estrogen metabolites also can increase the the risk of osteoporosis in men.