New target for treating diabetes and obesity
Researchers at Washington University School of Medicine in St. Louis have identified a potential target for treating diabetes and obesity. Studying mice, they found that when the target protein was disabled, the animals became more sensitive to insulin and were less likely to get fat.
Diabetes may start in the intestines, research suggests
Scientists at Washington University School of Medicine in St. Louis have made a surprising discovery about the origin of diabetes. Their research suggests that problems controlling blood sugar — the hallmark of diabetes — may begin in the intestines. The new study, in mice, may upend long-held theories about the causes of the disease.
Researchers discover root cause of blood vessel damage in diabetes
Diabetes researchers at Washington University School of Medicine in St. Louis have identified a key mechanism that appears to contribute to the blood vessel damage that occurs in people with diabetes.
Inhibiting fatty acids in immune cells decreases atherosclerosis risk
Scientists at Washington University School of Medicine in St. Louis have found a way to significantly reduce atherosclerosis in mice that does not involve lowering cholesterol levels or eliminating other obesity-related problems. Atherosclerosis is the process through which fatty substances, such as cholesterol and cellular waste products accumulate in the lining of arteries. The research team inhibited atherosclerosis in the mice by interfering with production of a substance called fatty acid synthase, an enzyme that converts dietary sugars into fatty acids in the liver.