Relapse, poor survival in acute leukemia linked to genetic mutations that persist in remission
For patients with an often-deadly form of leukemia, new research by Timothy J. Ley, MD, and colleagues suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Errors in single gene may protect against heart disease
Rare mutations that shut down a single gene are linked to lower cholesterol levels and a 50 percent reduction in the risk of heart attack, according to new research led by Nathan Stitziel, MD, PhD, of the School of Medicine. The gene, called NPC1L1, is of interest because it is the target of the drug ezetimibe, often prescribed to lower cholesterol.
Mouse model paves way for lung cancer studies
Lung tumors from mutant mice show an abundance of abnormal, undifferentiated cells.Often mice are used to investigate cancer because their accelerated life spans allow discoveries to be made in a few months. But most strains of mice stay relatively free of lung tumors, even when exposed to heavy tobacco smoke, so there has been a shortage of models suitable for studying tobacco smoke-induced lung cancer. Now, cancer researchers at the School of Medicine have developed a strain of mice that readily develops lung tumors that have the same genetic mutations found in human lung tumors.
Mouse model paves way for lung cancer studies
Lung tumors from mutant mice show an abundance of abnormal, undifferentiated cells.Often mice are used to investigate cancer because their accelerated life spans allow discoveries to be made in a few months. But most strains of mice stay relatively free of lung tumors, even when exposed to heavy tobacco smoke, so there has been a shortage of models suitable for studying tobacco smoke-induced lung cancer. Now, cancer researchers at Washington University School of Medicine in St. Louis have developed a strain of mice that readily develops lung tumors that have the same genetic mutations found in human lung tumors.