genetics

A newly identified cancer biomarker could define a new subtype of breast cancer as well as offer a potential way to treat it, say researchers at Washington University School of Medicine in St. Louis. The biomarker is found frequently in breast cancers that have poorer outcomes and can be inhibited by a protein discovered in the same laboratory, which could become an effective drug against the breast cancer type.

Cleft palate has been linked to dozens of genes. During their investigation of one of these genes, researchers at Washington University School of Medicine in St. Louis were surprised to find that cleft palate occurs both when the gene is more active and when it is less active than normal. 

Traditional rice cultivation methods practiced in the isolated hillside farms of Thailand are helping preserve the genetic diversity of rice, one of the world’s most important food crops, according to a new study by researchers at Washington University in St. Louis and Chiang Mai University in Thailand.

The coconut has been popular in lore and on palates for centuries, yet little is known about the history of this palm’s domestication and dispersal around the world. Now, Kenneth M. Olsen, Ph.D., assistant professor of biology in Arts & Sciences, is embarking on the task of understanding the plant’s history by exploring the genetics of the coconut.

The coconut has been popular in lore and on palates for centuries, yet little is known about the history of this palm’s domestication and dispersal around the world. Now, Kenneth M. Olsen, Ph.D., assistant professor of biology in Arts & Sciences, is embarking on the task of understanding the plant’s history by exploring the genetics of the coconut.

A psychiatric geneticist at the School of Medicine is one of several principal investigators around the country who will participate in the Genes, Environment and Health Initiative (GEI), a unique collaboration between geneticists and environmental scientists. The $48 million initiative is sponsored by the National Institutes of Health (NIH). Laura Jean Bierut, M.D., professor of psychiatry at the School of Medicine, will head the national study of addiction, looking both at genetic and environmental factors that contribute to the problem.

The coconut has been popular in lore and on palates for centuries, yet little is known about the history of this palm’s domestication and dispersal around the world. Now, Kenneth M. Olsen, Ph.D., assistant professor of biology in Arts & Sciences, is embarking on the task of understanding the plant’s history by exploring the genetics of the coconut.

The next generation of consumers will be the true beneficiaries of the promise of genomics. But how will they make informed choices in a world resplendent with genomics products, including tools to predict disease and the engineered drugs to treat those diseases? The answer, says Sarah C.R. Elgin, Ph.D., WUSTL professor of biology in Arts & Sciences, is more genetics and genomics at every level of American education.

Smoking while pregnant combined with genetic factors greatly increases the risk of severe ADHD.Past research has suggested that both genes and prenatal insults — such as exposure to alcohol and nicotine — can increase the risk of attention-deficit/hyperactivity disorder (ADHD). But the identified increases in risk have been very modest. Now, a team of Washington University scientists has found that when those factors are studied together, risk of a severe type of ADHD greatly increases.

Courtesy of the National Cancer InstituteBreast cancer cells stained brown using an antibody that recognizes malignant cellsClinical studies are proving that the genetic profile of a tumor can greatly influence its response to anticancer treatments. WUSM physician Matthew Ellis is conducting research that aims to use the genetic profile of breast tumors to guide breast cancer therapy and ultimately to find new drugs for treating the disease.