The McDonnell Genome Institute at Washington University School of Medicine in St. Louis will receive $60 million from the National Institutes of Health (NIH) to study the genetics of common diseases, such as heart disease, diabetes, stroke, autism and epilepsy.
The genome is the instruction book for life. But reading that instruction book and carrying out its directives are controlled by the epigenome, which attaches chemical markers to DNA to activate or silence genes. For the first time, researchers at the School of Medicine and elsewhere have assembled a comprehensive map of the human epigenome.
Cats and humans have shared the same households for at least 9,000 years, but we still know very little about how our feline friends became domesticated. An analysis of the cat genome by School of Medicine researchers reveals some surprising clues. Pictured is a blue Abyssinian cat.
Scientists have decoded the genome of an intestinal parasite that causes hookworm, an illness that afflicts an estimated 700 million of the world’s poor. The parasitic worm lives in the soil and enters the body through the feet. By feeding on victims’ blood, the worms cause anemia and, in children, stunted growth and learning problems.
An international team of researchers has sequenced the genome of the elephant shark, a curious-looking fish with a snout that resembles the end of an elephant’s trunk. Pictured is lead researcher Byrappa Venkatesh, PhD, of A*STAR in Singapore, holding an elephant shark.
By analyzing the DNA in more than 3,000 tumors, scientists led by Li Ding, PhD, at The Genome Institute have identified 127 repeatedly mutated genes that likely drive the growth of a range of cancers in the body. The discovery sets the stage for devising new diagnostic tools and more personalized cancer treatments.
Scientists have decoded the genome of the platyfish, a cousin of the guppy and a popular choice for home aquariums. Scientists are interested in the fish because they tend to develop melanomas along the tail and fin.
A large team of scientists has decoded the genome of a sea lamprey – one of the few ancient, jawless species of vertebrates that has survived through the modern era.
By decoding the genomes of more than 1,000 people whose homelands stretch from Africa and Asia to Europe and the Americas, scientists have compiled a detailed catalog of human genetic variation to find the genetic roots of rare and common diseases in populations worldwide.
Decoding the DNA of patients with advanced breast cancer has allowed scientists to identify distinct cancer “signatures” that could help predict which women are most likely to benefit from estrogen-lowering therapy, while sparing others from unnecessary treatment.