Elastin and collagen serve as the body’s building blocks. Any genetic mutation short-circuiting their function can have a devastating, and often lethal, health impact. For the first time, new research led by engineers at Washington University in St. Louis takes a closer look at both genetic and mechanical attributes, to better understand a disorder that affects how elastin and collagen function.
Older mice genetically prone to bear offspring with heart defects can reduce this risk to that of younger mouse mothers with the same genetic defect through exercise alone, according to new research at the School of Medicine. The study, led by Patrick Y. Jay, MD, PhD, also suggests that the increased risk of congenital heart defects is tied to the age of the mother and not the age of her eggs.