Building on a growing body of work that suggests dietary nitrate improves muscle performance in many elite athletes, researchers at Washington University School of Medicine in St. Louis found that drinking concentrated beet juice — high in nitrates — increases muscle power in patients with heart failure.
The heart holds its own pool of immune cells capable of helping it heal after injury, according to new research in mice at Washington University School of Medicine in St. Louis.
Large regions of the genome that were once referred to as “junk” DNA have been linked to human heart failure, according to research led by Jeanne Nerbonne, PhD, of Washington University School of Medicine in St. Louis.
Widely used treatments for type 2 diabetes have different effects on the hearts of men and women, even as the drugs control blood sugar equally well in both sexes, according to researchers at the School of Medicine. The investigators used PET scans to measure heart and whole-body metabolism in patients taking common diabetes drugs. Pictured are researchers Janet B. McGill, MD, and Robert J. Gropler, MD.
School of Medicine researchers have described a missing link in understanding how damage to the body’s cellular power plants leads to Parkinson’s disease and some forms of heart failure. A mouse heart, in gray, shows signs of heart failure because it is missing a newly discovered key molecule in the process that culls unhealthy mitochondria from cells. Superimposed on the heart is a fruit fly heart tube, shown in color. It shows signs of failure because it is missing another key molecule in mitochondrial quality control.
The National Institutes of Health has awarded more than $2 million to a team of scientists from Washington University in St. Louis and InvivoSciences, a biotechnology startup with WUSTL roots, to construct artificial tissue models that will allow the rapid testing of new drugs for heart failure.
Results of one of the largest studies of heart failure to date show that warfarin is no better than aspirin in reducing the combined risks of brain hemorrhage, stroke and death in most heart failure patients. Clinicians now have reassurance that aspirin is safe for heart failure patients with a normal heart rhythm, according to study co-author Douglas L. Mann, MD.
Washington University School of Medicine in St. Louis is organizing a Missouri-wide Heart Failure Clinical Research Network, sponsored by the National Institutes of Health (NIH). Cardiology Chief Douglas L. Mann, MD, says this clinical research consortium is one of only nine regional centers across the country investigating innovative treatments for heart failure.
Though some cardiologists may have dabbled in musical pursuits from an early age, few have opened for Aerosmith. How does one who dropped out of college to play drums and follow dreams of being a professional musician end up chief of cardiology at a major medical school? “I needed a day job,” says Douglas L. Mann, MD. Today, Mann studies inflammation and its role in heart failure.
Scientists, including Gerald W. Dorn, MD, have identified the first DNA sequence variant common in the population that is not only associated with an increased risk of heart failure, but appears to play a role in causing it.