hormones

Whether made by the body or ingested through diet, cholesterol plays a vital role in cells. Cholesterol also is a building block of steroids and hormones, including those that trigger puberty and support pregnancy. A new study, led by Daniel Ory, MD, implicates a surprising regulator of cholesterol in cells’ ability to make these hormones, especially in tissues associated with fertility, such as the ovaries.

DXA scans of a male patient with osteoporosisAlthough women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating – or even life-threatening – fractures. In women, low estrogen levels after menopause have been considered an important risk factor for this disorder. Now research at the School of Medicine has shown that low amounts of active estrogen metabolites also can increase the the risk of osteoporosis in men.

DXA scans of a male patient with osteoporosisAlthough women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating – or even life-threatening – fractures. In women, low estrogen levels after menopause have been considered an important risk factor for this disorder. Now research at Washington University School of Medicine in St. Louis has shown that low amounts of active estrogen metabolites also can increase the the risk of osteoporosis in men.