inflammation

Working in mice, surgeons and scientists at Washington University School of Medicine in St. Louis, have captured the first images of a beating heart at a resolution so detailed they can track individual immune cells swarming into the heart muscle, causing the inflammation that is so common after a heart attack or heart surgery.

Researchers at Washington University School of Medicine in St. Louis have found that problems with a digestive process in cells can clog arteries. The finding could provide a target for future therapies aimed at preventing or reversing atherosclerosis.

Scientists at Washington University School of Medicine in St. Louis have made a surprising discovery about the origin of diabetes. Their research suggests that problems controlling blood sugar — the hallmark of diabetes — may begin in the intestines. The new study, in mice, may upend long-held theories about the causes of the disease.

Researchers have identified the first genetic variant associated with severity of coronary artery disease in patients with type 2 diabetes. Though this variant is not likely the cause of more severe coronary disease, the researchers say, it implicates a gene that could be. Such a gene has promise as a future target for treating coronary artery disease in diabetic patients.

Though some cardiologists may have dabbled in musical pursuits from an early age, few have opened for Aerosmith. How does one who dropped out of college to play drums and follow dreams of being a professional musician end up chief of cardiology at a major medical school? “I needed a day job,” says Douglas L. Mann, MD. Today, Mann studies inflammation and its role in heart failure.

Consistent exercise is associated with a lower risk of dying from colon cancer, according to a new study led by Siteman Cancer Center researchers. The study is among the first to show that physical activity can make the disease less deadly. 

An abdominal MRI scan showing the locations of subcutaneous and visceral fatAs scientists learn more about the key role of inflammation in diabetes, heart disease and other disorders, new research from the School of Medicine suggests that fat in the belly may be an important promoter of that inflammation. It’s well known that excess fat is associated with disease, but the researchers have confirmed that fat cells inside the abdomen are secreting molecules that increase inflammation. It’s the first evidence of a potential mechanistic link between abdominal fat and systemic inflammation.

An abdominal MRI scan showing the locations of subcutaneous and visceral fatAs scientists learn more about the key role of inflammation in diabetes, heart disease and other disorders, new research from Washington University School of Medicine in St. Louis suggests that fat in the belly may be an important promoter of that inflammation. It’s well known that excess fat is associated with disease, but the researchers have confirmed that fat cells inside the abdomen are secreting molecules that increase inflammation. It’s the first evidence of a potential mechanistic link between abdominal fat and systemic inflammation. More…

Right now there’s no rapid way to diagnose sepsis, a fast-moving blood infection that is a leading cause of death in hospital intensive care units. Doctors who suspect sepsis typically rush to prescribe powerful antibiotics, but this can lead to the inappropriate treatment of patients with uncontrollable inflammation without an underlying infection. New research at the School of Medicine suggests that doctors one day could quickly distinguish sepsis from widespread non-infectious inflammation based on genetic profiles of patients’ blood.

Right now there’s no rapid way to diagnose sepsis, a fast-moving blood infection that is a leading cause of death in hospital intensive care units. Doctors who suspect sepsis typically rush to prescribe powerful antibiotics, but this can lead to the inappropriate treatment of patients with uncontrollable inflammation without an underlying infection. New research at Washington University School of Medicine in St. Louis suggests that doctors one day could quickly distinguish sepsis from widespread non-infectious inflammation based on genetic profiles of patients’ blood.