Sports medicine specialists at Washington University School of Medicine in St. Louis, including Rick Wright, MD, and Corey Gill, MD, are leading a national study analyzing why a second surgery to reconstruct a tear in the knee’s anterior cruciate ligament (ACL) carries a high risk of bad outcomes. Between 1 percent to 8 percent of ACL repairs fail. Most patients then opt to have a second operation, but the failure rate for those subsequent surgeries is almost 14 percent.
A five-year, $3.7 million clinical trial will investigate how to balance the benefits and risks of warfarin, a drug that helps prevent potentially deadly blood clots. The multicenter study, led by researchers at Washington University School of Medicine in St. Louis, will evaluate customized warfarin dosage based on patient genetics and will test which range of blood clotting is optimal in orthopedic patients.