Study uncovers hard-to-detect cancer mutations ​

Study uncovers hard-to-detect cancer mutations ​

New research, led by Li Ding, PhD, shows that current genome analysis approaches systematically miss detecting a certain type of complex mutation in cancer patients’ tumors. A significant percentage of these complex mutations are found in well-known cancer genes that could be targeted by existing drugs, potentially expanding the number of cancer patients who may benefit.

Genetic errors identified in 12 major cancer types

By analyzing the DNA in more than 3,000 tumors, scientists led by Li Ding, PhD, at The Genome Institute have identified 127 repeatedly mutated genes that likely drive the growth of a range of cancers in the body. The discovery sets the stage for devising new diagnostic tools and more personalized cancer treatments.

Wilson named world’s ‘Hottest Researcher’

Richard Wilson, PhD, director of The Genome Institute at Washington University School of Medicine, was named the world’s most-cited researcher by Thomson Reuters’ ScienceWatch. The list of most influential researchers also included Elaine Mardis, PhD, Li Ding, PhD, and Robert Fulton, all of The Genome Institute.