Better together: Mitochondrial fusion supports cell division

Better together: Mitochondrial fusion supports cell division

New research from Gary Patti’s laboratory in Arts & Sciences shows that when cells divide rapidly, their mitochondria are fused together. In this configuration, the cell is able to more efficiently use oxygen for energy. This work illuminates the inner workings of dividing cells and shows how mitochondria combine to help cells to multiply in unexpected ways.
Metabolomics for the masses

Metabolomics for the masses

Gary Patti, the Michael and Tana Powell Associate Professor of Chemistry in Arts & Sciences at Washington University in St. Louis, has been awarded $4.8 million in two separate National Institutes of Health (NIH) grants focused on improving the accessibility of metabolomics — the study of the biochemical reactions that underlie metabolism.
Challenging an old idea

Challenging an old idea

For more than 80 years, scientists have thought that cancer cells fuel their explosive growth by soaking up glucose from the blood, using its energy and atoms to crank out duplicate sets of cellular components. But is this really true? Work in a metabolomics laboratory at Washington University in St. Louis suggests not.
Fat signals control energy levels in the brain

Fat signals control energy levels in the brain

An enzyme secreted by the body’s fat tissue controls energy levels in the brain, according to new research led by Shin-ichiro Imai, MD, PhD, of the School of Medicine. The findings, in mice, underscore a role for the body’s fat tissue in controlling the brain’s response to food scarcity, and suggest there is an optimal amount of body fat for maximizing health and longevity.
Not all obese people develop metabolic problems linked to excess weight​​​​

Not all obese people develop metabolic problems linked to excess weight​​​​

New research demonstrates that obesity does not always go hand in hand with metabolic changes in the body that can lead to diabetes, heart disease and stroke. Washington University School of Medicine researchers found that a subset of obese people do not have common metabolic abnormalities associated with obesity, and they don’t develop them when they gain more weight.​

Resveratrol falls short in health benefits

Resveratrol, an ingredient in red wine thought to improve insulin sensitivity, reduce risk of heart disease and increase longevity, does not appear to have those benefits in healthy women, according to new research from Washington University School of Medicine in St. Louis.
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