Methadone’s side effects, efficacy may be linked to genetic makeup​

Methadone — long used to treat pain and addiction — can be lethal if it lingers too long in the body. New research led by the School of Medicine’s Evan D. Kharasch, MD, PhD, has identified genetic subtypes in people that govern methadone clearance, findings that could help prevent some of the 5,000 methadone-related deaths that occur each year in the United States.