Seeing melanoma

Two scientists at Washington University in St. Louis are able to image subcutaneous melanoma tumors with startling clarity. Their imaging technique relies on sound rather than light because sound is less strongly scattered by tissues. In addition, the tumors are preloaded with a nanoparticle contrast agent that latches onto proteins that stud the surface of the cancerous cells.

Novel technique changes lymph node biopsy, reduces radiation exposure in breast cancer patients

David Kilper/WUSTL PhotoWUSTL biomedical engineers Younan Xia (left) and Lihong Wang examine the photoacoustic tomography machine (PAT) in Wang’s Whitaker Building laboratory.Information obtained from a new application of photoacoustic tomography (PAT) is worth its weight in gold to breast cancer patients. For the first time, Lihong Wang, Ph.D., Gene K. Beare Distinguished Professor in the Department of Biomedical Engineering, with a joint appointment in Radiology, and Younan Xia, Ph.D., James M. McKelvey Professor in Biomedical Engineering, with a joint appointment in chemistry in Arts & Sciences, both at Washington University in St. Louis, have used gold nanocages to map sentinel lymph nodes (SLN) in a rat noninvasively using PAT.