Study shows who benefits most from statins

Study shows who benefits most from statins

New research suggests that widely used statin therapy provides the most benefit to patients with the highest genetic risk of heart attack. Using a relatively straightforward genetic analysis, the researchers, including Nathan O. Stitziel, MD, PhD, assessed heart attack risk independently of the traditional risk factors.

Errors in single gene may protect against heart disease

Rare mutations that shut down a single gene are linked to lower cholesterol levels and a 50 percent reduction in the risk of heart attack, according to new research led by Nathan Stitziel, MD, PhD, of the School of Medicine. The gene, called NPC1L1, is of interest because it is the target of the drug ezetimibe, often prescribed to lower cholesterol.