New clues identified in childhood cancer syndrome

New clues identified in childhood cancer syndrome

New research from David Gutmann, MD, PhD, may help doctors determine which medical issues are likely to manifest in patients with the inherited cancer syndrome neurofibromatosis type 1 (NF1). The findings indicate that varying mutations in the NF1 gene may lead to different clinical outcomes.
Stem cells lurking in tumors can resist treatment​​​​

Stem cells lurking in tumors can resist treatment​​​​

Scientists are eager to make use of stem cells’ extraordinary power to transform into nearly any kind of cell, but that ability also is cause for concern in cancer treatment. New research at the School of Medicine has revealed that these stem cells are present even in slow-growing, less aggressive tumors.

Brain scans reveal drugs’ effects on attention

Scientists have developed a way to evaluate new treatments for some forms of attention deficit disorder. Working in mice, researchers at the School of Medicine showed that they can use brain scans to quickly test whether drugs increase levels of dopamine. The same group found that raising dopamine levels in mice alleviates attention deficits caused by neurofibromatosis type 1 (NF1), a condition that affects more than 100,000 people in the United States.

Finding may help prevent vision loss in tumor disorder

Nerve cells in the body and brain react in opposite ways to the loss of a protein linked to a childhood tumor syndrome, researchers at Washington University School of Medicine in St. Louis have found. The finding could be important to efforts to preserve the vision of patients with neurofibromatosis 1, a genetic condition that increases risk of benign and malignant brain tumors.
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