positron emission tomography

Researchers led by Samuel Achilefu, PhD, at the School of Medicine have devised a way to apply light-based therapy to deep tissues never before accessible. Instead of shining an outside light, they delivered light directly to tumor cells, along with a photosensitive source of free radicals that can be activated by the light to destroy cancer.

In this PET image, the arrow shows inflammation of the lungs.A noninvasive approach for assessing lung inflammation should accelerate efforts to develop drugs for inflammatory lung conditions like cystic fibrosis and pneumonia, scientists at the School of Medicine report. Researchers have used positron emission tomography (PET) scans to monitor artificially induced inflammation in the lungs of healthy volunteers. The new imaging process may help doctors monitor the conditions of patients with inflammatory lung diseases and should make it easier for investigators to test potential anti-inflammatory drugs.

In this PET image, the arrow shows inflammation of the lungs.A noninvasive approach for assessing lung inflammation should accelerate efforts to develop drugs for inflammatory lung conditions like cystic fibrosis and pneumonia, scientists at Washington University School of Medicine in St. Louis report. Researchers have used positron emission tomography (PET) scans to monitor artificially induced inflammation in the lungs of healthy volunteers. The new imaging process may help doctors monitor the conditions of patients with inflammatory lung diseases and should make it easier for investigators to test potential anti-inflammatory drugs.

PET scans: normal (top 2 rows) and Alzheimer’s.After decades of searching, scientists finally may have identified a way to study Alzheimer’s disease changes in living human brains. Researchers at Washington University’s Alzheimer’s Disease Research Center (ADRC) have begun studies of an imaging agent developed at the University of Pittsburgh that could potentially detect amyloid plaques with a positron emission tomography (PET) scan, enabling earlier detection of the disease and improved testing of new treatments.

GrigsbyDoctors regularly use positron emission tomography (PET) scans to diagnose cervical cancer, taking advantage of the technique’s ability to highlight metabolic differences in cancerous tissues. But PET is rarely used for follow-up assessment of cervical cancer patients after treatment. A study in the June 1 issue of Journal of Clinical Oncology shows that post-treatment PET scans could help physicians better predict which patients are largely cancer-free as a result of their treatment and which patients may soon be likely to need additional treatment.

Areas of red and yellow show increased uptake of the altanserin tracer due to binding to the serotonin receptors.Most of us feel sad from time to time, even very sad, but during a bout of clinical depression, a person is unable to escape their low mood for several weeks at a time. A popular and effective treatment for depression involves a class of drugs called selective serotonin reuptake inhibitors (SSRIs). Those drugs increase serotonin levels in the brain and help relieve symptoms of depression, and most scientists believe the brain chemical serotonin plays a key role in depression. Now neuroscience researchers at Washington University School of Medicine in St. Louis have found that in people who are depressed, a key brain structure has an abnormally low number of cellular serotonin receptors.