In lung cancer, smokers have 10 times more genetic damage than never-smokers
Lung cancer patients with a history of smoking have ten times more genetic mutations in their tumors than those with the disease who have never smoked, according to Richard K. Wilson, PhD, and his colleagues at Washington University School of Medicine in St. Louis.
Mutations in single gene predict poor outcomes in adult leukemia
Decoding the DNA of a woman who died of acute myeloid leukemia has led Washington University researchers to a gene that they found to be commonly altered in many patients who died quickly of the disease.
New subtype of breast cancer responds to targeted drug
A newly identified cancer biomarker could define a new subtype of breast cancer as well as offer a potential way to treat it, say researchers at Washington University School of Medicine in St. Louis. The biomarker is found frequently in breast cancers that have poorer outcomes and can be inhibited by a protein discovered in the same laboratory, which could become an effective drug against the breast cancer type.