The acidity of urine — as well as the presence of small molecules related to diet — may influence how well bacteria can grow in the urinary tract, a new study shows. The research, led by Jeffrey Henderson, MD, PhD, at Washington University School of Medicine in St. Louis, may have implications for treating urinary tract infections, which are among the most common bacterial infections worldwide.
The most common type of hospital-associated infection may be preventable with a vaccine, new research in mice suggests. The experimental vaccine, created by School of Medicine researchers, prevented urinary tract infections associated with catheters, the tubes that hospitals and other care facilities insert to drain urine from the bladder.
Washington University’s Global Health Center selected five WUSTL students for its inaugural summer research program, which paired students with faculty mentors to explore issues such as malnutrition, maternal health and access to health care. Pictured is program participant Laura Bliss, a second-year medical student.
Women plagued by repeated urinary tract infections may be able to prevent them with help from over-the-counter painkillers, new research in mice shows. School of Medicine scientists found that inhibiting an immune protein that causes inflammation eliminated recurrent urinary tract infections in mice.
Urinary tract infections are among the most common infections acquired in hospitals, with most linked to the use of catheters. New research suggests that some urinary tract infections could be prevented if patients receive an antibiotic at the time they have a urinary catheter removed.
Humans have known for centuries that copper is a potent weapon against infection. New research shows that the bacteria that cause serious urinary tract infections “know” this, too, and steal copper to prevent the metal from being used against them. Blocking this thievery with a drug may significantly improve patients’ chances of fighting off infections, according to researchers.
Scientists at Washington University School of Medicine in St. Louis have found new clues to why some urinary tract infections recur persistently after multiple rounds of treatment. Their research, conducted in mice, suggests that the bacteria that cause urinary tract infections take advantage of a cellular waste disposal system that normally helps fight invaders.
An experimental treatment for urinary tract infections has easily passed its first test in animals, alleviating weeks-long infections in mice in as little as six hours.
Innovative new studies at the School of Medicine will evaluate novel strategies for reducing infections in health-care settings. The research, led by Victoria Fraser, MD, is funded by a grant from the U.S. Centers for Disease Control and Prevention.
The schematic in the center shows how a drug molecule (in the circle) prevents UTIs by stopping pili formation.A different approach to treating urinary tract infections (UTIs) could defeat the bacteria that cause the infections without directly killing them, a strategy that could help slow the growth of antibiotic-resistant infections. Instead of trying to wipe out bacteria, researchers at the School of Medicine have been working to create pharmaceuticals that essentially “defang” the bacteria by preventing them from assembling pili, microscopic hairs that enable the bacteria to invade host cells and defend themselves against the host’s immune system.