viruses

Studying mice with a variety of viral infections, scientists at the School of Medicine have demonstrated a way to dial up the body’s innate immune defenses while simultaneously attacking a protein that many viruses rely on to replicate. The findings reveal previously unknown weapons in the body’s antiviral immune arsenal and provide guidelines for designing drugs that could be effective against a broad range of viruses.

Bacteria aren’t the only non-human invaders to colonize the gut shortly after a baby’s birth. Viruses also set up house there, according to new research led by Lori Holtz, MD, at Washington University School of Medicine in St. Louis.

Using antibodies from camels and alpacas, scientists led by David T. Curiel, MD, PhD, at Washington University School of Medicine in St. Louis have found a way to deliver anticancer viruses directly to tumor cells, leaving other types of cells uninfected. The discovery may solve a longstanding problem in the field of gene therapy.

A provocative study links prolonged episodes of sepsis — a life-threatening infection and leading cause of death in hospitals — to the reactivation of otherwise dormant viruses in the body. Pictured is the Epstein-Barr virus.

Not all viruses make us sick. But which ones are friends and which ones are foes? Researchers, led by Gregory Storch, MD, at Washington University School of Medicine in St. Louis have received a five-year, $3.3 million grant to study children with weakened immune systems to identify the viruses that make children sick.

A largely unexplored world of viruses make their home in the lower intestine, and new research at Washington University School of Medicine in St. Louis suggests that each of us harbors a unique collection of these “friendly” viruses. The research is published in the journal Nature.

John Lockwood programs the data enabling device to stop the SoBig worm.A computer scientist at Washington University in St. Louis has developed technology to stop malicious software – malware – such as viruses and worms long before it even has a chance to reach computers in the home and office. John Lockwood, Ph.D., an assistant professor of computer science at Washington University, and the graduate students that work in his research laboratory have developed a hardware platform called the Field-programmable Port Extender (FPX) that scans for malware transmitted over a network and filters out unwanted data.