Fat in the liver — not the belly — is a better marker for disease risk

New findings from nutrition researchers at the School of Medicine suggest that it’s not whether body fat is stored in the belly that affects metabolic risk factors for diabetes, high blood triglycerides and cardiovascular disease, but whether it collects in the liver. They report online in the journal PNAS Early Edition that when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body’s ability to metabolize sugar.

Belly fat may drive inflammatory processes associated with disease

An abdominal MRI scan showing the locations of subcutaneous and visceral fatAs scientists learn more about the key role of inflammation in diabetes, heart disease and other disorders, new research from the School of Medicine suggests that fat in the belly may be an important promoter of that inflammation. It’s well known that excess fat is associated with disease, but the researchers have confirmed that fat cells inside the abdomen are secreting molecules that increase inflammation. It’s the first evidence of a potential mechanistic link between abdominal fat and systemic inflammation.

Belly fat may drive inflammatory processes associated with disease

An abdominal MRI scan showing the locations of subcutaneous and visceral fatAs scientists learn more about the key role of inflammation in diabetes, heart disease and other disorders, new research from Washington University School of Medicine in St. Louis suggests that fat in the belly may be an important promoter of that inflammation. It’s well known that excess fat is associated with disease, but the researchers have confirmed that fat cells inside the abdomen are secreting molecules that increase inflammation. It’s the first evidence of a potential mechanistic link between abdominal fat and systemic inflammation. More…