Research Wire: November 2016

Kelle H. Moley, MD, the James Crane Professor of Obstetrics & Gynecology and director of the Center for Reproductive Health Sciences at the School of Medicine, has received $1.98 million from the National Institutes of Health (NIH)’s National Institute of Child Health and Human Development for a renewed five-year study on “Molecular and Metabolic Aspect of Implantation.” The project should have an important impact on the fertility field by revealing mechanisms critical to successful decidualization, implantation and overall pregnancy outcomes.

Andreas Herrlich, MD, PhD, associate professor of medicine at the School of Medicine, received a $1.125 million, five-year grant from the National Institute of Health (NIH)’s National Institute of Diabetes and Digestive and Kidney Diseases for research titled “The Role of ADAM17 Substrates in Progressive Kidney Disease.” Herrlich’s goal is to to define the molecular mechanism by which ADAM17 and its substrates contribute to progressive kidney disease and to evaluate the therapeutic potential of inhibiting the pathways involved.

David Fike, associate professor of earth and planetary sciences in Arts & Sciences, and Jocelyn Richardson, a PhD candidate in geochemistry, will receive a $110,000 grant from the American Chemical Society to undertake a project titled “New Approaches to Reconstructing the Timing of Diagenesis and Porosity Evolution in Sedimentary Carbonate Strata.” Their research will take advantage of the university’s state-of-the-art secondary ion mass spectrometry system along with advanced X-ray spectromicroscopy techniques.

William McKinnon, professor of earth and planetary sciences in Arts & Sciences, received $64,000 from the U.S. Geological Survey and NASA to study thrust faulting in rock and ice lithosphere in the outer solar system. McKinnon also received a grant of $40,000 from the Southwest Research Institute for research related to a mission to Jupiter’s moon Europa.

Morgan Raven, a postdoctoral research associate in earth and planetary sciences in Arts & Sciences, was awarded a two-year fellowship from the Agouron Institute to support her research in stable isotope biogeochemistry.

ShiNung Ching and Jr-Shin Li, of the School of Engineering & Applied Science, are working on methods to get a specific reaction from particular cells in the brain, thanks to a National Eye Institute grant. They are working with Jason T. Ritt of Boston University.

The two-year, $254,496 grant is part of the National Institutes of Health (NIH)’s Brain Research through Advancing Innovating Neurotechnologies (BRAIN) Initiative, a large-scale investment launched by President Barack Obama in 2013 to equip researchers with insights necessary to treat a wide array of brain disorders. Read more on the engineering site.

Michael Avidan, MBBCh, professor of anesthesiology and of cardiothoracic surgery at the School of Medicine, and Yixin Chen, professor of computer science and engineering in the School of Engineering & Applied Science, are co-principal investigators on a two-year, $589,998 grant from the National Science Foundation to develop, validate and assess machine-learning, forecasting algorithms that predict adverse outcomes for individual patients.

Indira Mysorekar, associate professor of obstetrics and gynecology and of pathology and immunology, and associate director of the Center for Reproductive Health Sciences at the School of Medicine, has received a $1.56 million, five-year grant from the National Institutes of Health (NIH)’s National Institute on Aging for research titled “Interleukin-6 and Aging: Impact on Immune Defense and Tissue Repair in Urinary Bladder.” The grant will be used to study how estrogen regulates the course of urinary tract infections and bladder recovery after infection. The hope is that the work leads to development of therapeutic interventions for the disease in aging menopausal populations.

Vijay Ramani, of the School of Engineering & Applied Science, received a three-year, $468,087 grant from the Office of Naval Research to create a stable, bipolar membrane for fuel cell propulsion systems that would enable the U.S. Navy’s unmanned undersea vehicles to fulfill challenging mission requirements. Read more on the engineering website. 

Christine Floss, research professor of physics in Arts & Sciences, has been awarded $30,000 from NASA to support a project titled “Characterizing Comet 81P/Wild 2 with Acfer 094 and Tagish Lake Analog Foils.”

Crickette Sanz, associate professor in anthropology in Arts & Sciences, and David Morgan, research associate in anthropology, received a $20,000 grant from the Columbus Zoological Park Association to undertake research titled “Goualougo Triangle Ape Project: Developing Conservation Policies and Local Leadership to Ensure the Long-Term Survival of Chimpanzees and Gorillas in the Congo Basin.”

Marina Gross, a University Fellow in psychological and brain sciences in Arts & Sciences, received a $1,000 grant from the American Psychological Association of Graduate Students for research on using pupillometry to separate attention from effort and study the influence of time pressure.

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