Alzheimer’s disease

Washington University in St. Louis is recognizing Charles F. and Joanne Knight by naming its world-renowned Alzheimer’s Disease Research Center (ADRC) in their honor.

Older adults with evidence of amyloid in the brain but no clinical symptoms of Alzheimer’s disease have structures in the brain that don’t communicate readily with each other, according to researchers at Washington University School of Medicine in St. Louis. The findings may be yet another indicator that Alzheimer’s damage to the brain begins to occur long before there are clinical symptoms of the disease.  

Three faculty members of the School of Medicine will be honored by the Academy of Science of St. Louis: Randall Bateman, M. Carolyn Baum and Alan L. Schwartz.

Researchers at Washington University School of Medicine in St. Louis have received a five-year, $3.8 million grant from the National Institute of Neurological Disorders and Stroke to renew a center that helps researchers collect and use data on the brain and central nervous system.

Preventing Alzheimer’s disease is a goal of Raphael Kopan, Ph.D., professor of molecular biology and pharmacology at the Washington University School of Medicine. The moss plant Physcomitrella patens, studied in the laboratory of Ralph S. Quatrano, Ph.D., the Spencer T. Olin Professor and chair of the biology department on WUSTL’s Danforth Campus, might inch Kopan toward that goal.

The surge of baby boomers now entering their 60s means more drivers on the road who may be impaired by dementia or other cognitive impairments linked to aging. Researchers at the Alzheimer’s Disease Research Center (ADRC) at the School of Medicine and elsewhere have developed a three-hour workshop that trains health care providers to identify potentially unsafe drivers with dementia and to encourage appropriate retirement from driving.

The surge of baby boomers now entering their 60s means more drivers on the road who may be impaired by dementia or other cognitive impairments linked to aging. Researchers at the Alzheimer’s Disease Research Center (ADRC) of Washington University School of Medicine in St. Louis and elsewhere have developed a three-hour workshop that trains health care providers to identify potentially unsafe drivers with dementia and to encourage appropriate retirement from driving.

Tasks requiring shifting of attention, like driving a car while conversing with a passenger, may be challenging for people in very early stages of Alzheimer’s disease.People in early stages of Alzheimer’s disease have greater difficulty shifting attention back and forth between competing sources of information, a finding that offers new support for theories that contend breakdowns in attention play an important role in onset of the disease. Published in a recent issue of the journal Neuropsychology, the study suggests that subtle breakdowns in attention may offer one of the earliest reliable clues that a patient is grappling with early symptoms of Alzheimer’s-related dementia.

PET scans: normal (top 2 rows) and Alzheimer’s.After decades of searching, scientists finally may have identified a way to study Alzheimer’s disease changes in living human brains. Researchers at Washington University’s Alzheimer’s Disease Research Center (ADRC) have begun studies of an imaging agent developed at the University of Pittsburgh that could potentially detect amyloid plaques with a positron emission tomography (PET) scan, enabling earlier detection of the disease and improved testing of new treatments.

Joe Angeles / WUSTL PhotoA new book co-authored by a memory researcher at Washington University in St. Louis is one-stop shopping for all the questions we have about memory and how serious our lapses might be as we grow older. Mark A. McDaniel, Ph.D., professor of psychology in Arts & Sciences at WUSTL, says his book, Memory Fitness: A Guide for Successful Aging, relies on many rigorous academic studies but is written for the lay person. “Our mission is to give the general public a good idea of what they can reasonably expect from their memory capabilities as they age,” says McDaniel about the book he co-authored with Gilles O. Einstein, Ph.D., professor and chair of the psychology department at Furman University. “It also outlines some reasonable expectations about things people can do to perhaps increase their memory performances.”