bacteria

Disease-causing bacteria’s efforts to resist antibiotics may get help from their distant bacterial relatives that live in the soil, new research by Kevin Forsberg, a graduate student at Washington University School of Medicine suggests. The researchers found identical genes for antibiotic resistance in soil bacteria and in pathogens from clinics around the world.

An experimental treatment for urinary tract infections has easily passed its first test in animals, alleviating weeks-long infections in mice in as little as six hours.

Indira Mysorekar and a team of researchers at the School of Medicine are studying asymptomatic infections in the placenta and uterine lining to see if they may play a role in preterm birth.  

Bacteria often attack with toxins designed to hijack or even kill host cells. To avoid self-destruction, bacteria have ways of protecting themselves from their own toxins. Now, researchers have described one of these protective mechanisms, potentially paving the way for new classes of antibiotics that cause the bacteria’s toxins to turn on themselves.

A largely unexplored world of viruses make their home in the lower intestine, and new research at Washington University School of Medicine in St. Louis suggests that each of us harbors a unique collection of these “friendly” viruses. The research is published in the journal Nature.

Robert Kranz has devoted much of his caeer to understanding cytochrome c, a little-noted molecule but one as important to life as DNA or hemoglobin. Because bacteria and people use different systems to assemble this molecule, his work may open the door to novel antibiotics and other medicinal drugs.

Researchers at Washington University in St. Louis have figured out the orientation of a protein in the antenna complex to its neighboring membrane in a photosynthetic bacterium, a key find in the process of energy transfer in photosynthesis. Robert Blankenship, Ph.D., Markey Distinguished Professor of Biology and Chemistry in Arts & Sciences, led a team that for the first time combined chemical labeling with mass spectroscopy to verify the orientation. The team also included Michael Gross, Ph.D., WUSTL Professor of Chemistry, Immunology and Medicine, and Chemistry graduate students Jianzhong Wen and Hao Zhang. A paper describing this work appeared recently in the Proceedings of the National Academy of Sciences USA.

Researchers at Washington University in St. Louis are proposing to borrow a process used in breweries and wastewater treatment facilities to make corn ethanol more energy efficient. They are exploring the use of oxygen-less vats of microorganisms that naturally feed on organic waste produced from the ethanol fermentation process.

Researchers at Washington University in St. Louis are the first to identify two proteins responsible for mechanosensitive ion channel activities in plant roots. Scientists have long known that plant cells respond to physical forces. Until now, however, the proteins controlling the ion channel response remained a mystery.

Researchers at Washington University in St. Louis have gained the first detailed insight into the way circadian rhythms govern global gene expression in Cyanothece, a type of cyanobacterium (blue-green algae) known to cycle between photosynthesis during the day and nitrogen fixation at night.