An ‘unprecedented look’ into the protein behind hypertension, epilepsy and other conditions
The seemingly unrelated conditions of hypertension, epilepsy and overactive bladder may be linked by electrical activity in a protein long studied by a biomedical engineer at Washington University in St. Louis. After new technology recently revealed the structure of the protein, his lab will collaborate with two others to take an unprecedented look into its molecular mechanisms, potentially leading to the development of new drugs for these and other conditions.
Unusual protein helps regulate key cell communication pathway
Charged atoms, or ions, move through tiny pores, or channels, embedded in cell membranes, generating the electrical signals that allow cells to communicate with one another. In new research, scientists have shown how an unusual protein plays a key role in temporarily blocking the movement of ions through these channels. Preventing ions from moving through the channel gives cells time to recharge so that they can continue firing.