genome

The School of Medicine has received a $14.3 million grant through the American Recovery and Reinvestment Act to expand its high-powered data center for genomics. The facility’s sophisticated computer networks store massive amounts of genomic data used to identify the genetic origins of cancer and other diseases.

Washington University School of Medicine and St. Jude Children’s Research Hospital announced in a Jan. 25 news conference in Washington, D.C., an unprecedented effort to identify the genetic changes that give rise to some of the world’s deadliest childhood cancers.

Washington University is in the spotlight for its pivotal role in the Genomics Education Partnership, a collaborative effort to provide research experience in genomics to undergraduate classrooms across the country.

ElginWashington University in St. Louis is in the spotlight for its pivotal role in the Genomics Education Partnership, a collaborative effort to provide research experience in genomics to undergraduate classrooms across the country. At the helm of this mission is Sarah C.R. Elgin, Ph.D., WUSTL professor of biology and professor of education in Arts & Sciences, as well as professor of biochemistry & molecular biophysics and professor of genetics in the School of Medicine.

Researchers at WUSTL and Arizona State University have sequenced the genome of a rare bacterium that harvests light energy by making an even rarer form of chlorophyll, chlorophyll d. Chlorophyll d absorbs “red edge,” near infrared, long wave length light that is invisible to the naked eye. In so doing, the cyanobacterium Acaryochloris marina competes with virtually no other plant or bacterium in the world for sunlight.

Researchers at Washington University in St. Louis and Arizona State University have sequenced the genome of a rare bacterium that harvests light energy by making an even rarer form of chlorophyll, chlorophyll d. Chlorophyll d absorbs “red edge,” near infrared, long wave length light that is invisible to the naked eye. In so doing, the cyanobacterium Acaryochloris marina, competes with virtually no other plant or bacterium in the world for sunlight.

David Kilper/WUSTL PhotoRobert Blankenship, professor of biology and chemistry at Washington University in St. Louis, holds the cyanobacteria *Acaryochloris marina*, a rare bacterium that uses chlorophyll d for photosynthesis.Researchers at Washington University in St. Louis and Arizona State University have sequenced the genome of a rare bacterium that harvests light energy by making an even rarer form of chlorophyll, chlorophyll d. Chlorophyll d absorbs “red edge,” near infrared, long wave length light that is invisible to the naked eye. In so doing, the cyanobacterium Acaryochloris marina, competes with virtually no other plant or bacterium in the world for sunlight.

Photo by David Kilper / WUSTL PhotoKenneth Olsen, Ph.D., assistant professor of biology in Arts & Sciences, examines a cultivated rice plant in the Goldfarb Greenhouse.Red rice sounds like a New Orleans dish or a San Francisco treat. But it’s a weed, the biggest nuisance to American rice growers, who are the fourth largest exporters of rice in the world. And rice farmers hate the pest, which, if harvested along with domesticated rice, reduces marketability and contaminates seed stocks. Complicating matters is the fact that red rice and cultivated rice are exactly the same species, so an herbicide cannot be developed that seeks out only red rice. It would kill cultivated rice, too. But now a plant evolutionary biologist at Washington University in St. Louis has been funded by the National Science Foundation (NSF) at $1.12 million for two years to perform genetic studies on red rice to understand molecular differences between the two that someday could provide the basis for a plan to eradicate the weed. More…

This is *C. elegans*. Its genome was thought to have been completed until a WUSTL computer scientist found otherwise.A computer scientist at Washington University in St. Louis has applied software that he has developed to the genome of a worm and has found 150 genes that were missed by previous genome analysis methods. Moreover, using the software, he and his colleagues have developed predictions for the existence of a whopping 1,119 more genes.

Michael R. Brent and Tamara L. Doering examine data from the *C. neoformans* microarray.A team of collaborators, including two researchers from Washington University in St. Louis, has sequenced the genomes of two strains of the fungus Cryptococcus neoformans (C. neoformans), one which is virulent, the other harmless. This work provides researchers with clues on how the fungus does its dirty work and a host of genes to study for a better understanding of fungal pathogens in general. Estimates are that about 15 percent of people with HIV will suffer at least one life-threatening infection of C. neoformans. In Africa, that could be as much as 40 percent of HIV sufferers.