heart

​​Jianmin Cui, PhD, of the School of Engineering & Applied Science at Washington University in St. Louis, has received a nearly $1.7 million grant from the National Institutes of Health to study the molecular bases for the function of potassium channels vital for the heart, brain, inner ear and other tissues.

The heart holds its own pool of immune cells capable of helping it heal after injury, according to new research in mice at Washington University School of Medicine in St. Louis.

An investigational drug studied in animals significantly reduced damage to heart muscle from a heart attack and minimized the risk of bleeding during follow-up treatments, according to a study by scientists at the School of Medicine. Pictured is senior author Dana Abendschein, PhD.

Researchers at the School of Medicine have shown that two major pools of immune cells are at work in the heart. Both belong to a class of cells known as macrophages. One appears to promote healing, while the other likely drives inflammation, which is detrimental to long-term heart function.

Working in mice, surgeons and scientists at Washington University School of Medicine in St. Louis, have captured the first images of a beating heart at a resolution so detailed they can track individual immune cells swarming into the heart muscle, causing the inflammation that is so common after a heart attack or heart surgery.

Life-threatening bacterial infections and brain tumors are just some of the serious health issues affecting children. Now, 12 Washington University School of Medicine research teams are preparing to ask – and answer – critical questions about these and other pediatric health problems with help from $3 million in new grants from the Children’s Discovery Institute, led by Mary Dinauer, MD, PhD.

Doctors at Washington University School of Medicine in St. Louis are performing a new procedure to treat atrial fibrillation, a common irregular heartbeat. Available at only a handful of U.S. medical centers, this “hybrid” procedure combines minimally invasive surgical techniques with the latest advances in catheter ablation. The two-pronged approach gives doctors access to both the inside and outside of the heart at the same time, helping to more completely block the erratic electrical signals that cause atrial fibrillation.

Photo by David KilperLarry A.Taber, Ph.D., (left) the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Philip Bayly, Ph.D., the Hughes Professor of Mechanical Engineering, employ a microindentation device to measure the mechanical properties of embryonic hearts and brains. The researchers are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and more intellectual capacity) than a brain of comparable volume with a smooth surface.

Engineers at Washington University in St. Louis are finding common ground between the shaping of the brain and the heart during embryonic development. Larry A.Taber, Ph.D., the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Philip Bayly, Ph.D., the Hughes Professor of Mechanical Engineering, are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and hence more intellectual capacity) than a brain of comparable volume with a smooth surface.

David Kilper/WUSTL Photo(L-R) Larry Taber, postdoctoral researcher Gang Xu and Philip Bayly examine brain and heart cells to learn something of the mechanics involved in brain folding.Engineers at Washington University in St. Louis are finding common ground between the shaping of the brain and the heart during embryonic development. Larry A.Taber, Ph.D., the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Phillip Bayly, Ph.D., Hughes Professor of Mechanical Engineering, are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and hence more intellectual capacity) than a brain of comparable volume with a smooth surface.