psychiatry

Lifestyles and emotions play important roles in many medical illnesses, and when scientists study potential treatments to help people stop smoking, get more exercise, overcome depression or improve their diet, they often compare patients who get a certain treatment to others who don’t. Researchers at Washington University School of Medicine in St. Louis, led by Ken Freedland, MD, say to accurately measure a new therapy’s the effectiveness, it is critical to carefully define comparison — or control — groups in those studies.  

The saying “You are who you hang around with” seems especially true when it comes to alcohol, cigarette and drug use. Researchers at Washington University School of Medicine in St. Louis are reporting that people who hang out with marijuana, cigarette or alcohol users are not only more likely to do the same, but that exposure allows genetic tendencies for substance use to become more robust.  

Researchers at Washington University School of Medicine in St. Louis are studying people age 60 and older to determine whether augmenting medication for depression with a second drug might help older patients break free of clinical depression. Both study drugs are FDA-approved therapies for depression in younger adults, but the benefits need to be examined in older adults. 

A genome-wide study into the genetic roots of alcoholism has identified several areas of DNA that appear to contribute to the disease. But researchers say those genes make relatively modest contributions to overall risk of alcoholism.

A psychiatric geneticist at the School of Medicine is one of several principal investigators around the country who will participate in the Genes, Environment and Health Initiative (GEI), a unique collaboration between geneticists and environmental scientists. The $48 million initiative is sponsored by the National Institutes of Health (NIH). Laura Jean Bierut, M.D., professor of psychiatry at the School of Medicine, will head the national study of addiction, looking both at genetic and environmental factors that contribute to the problem.

Deanna Barch (center) discusses brain imaging techniques used in the experiment, which used the functional magnetic resonance imaging (fMRI) machine (shown at right).When encouraged to use memorization strategies commonly employed by healthy individuals, people with schizophrenia can be helped to remember information just as well as their healthy counterparts, a process that in itself seems to spur a normalization of memory-related activities in the brains of people with schizophrenia, suggests new research from Washington University in St. Louis.

Deanna Barch (right), co-author of a memory study that used a functional magnetic resonance imaging machine (shown in the background) to monitor the brain activity of people with schizophrenia.When encouraged to use memorization strategies commonly employed by healthy individuals, people with schizophrenia can be helped to remember information just as well as their healthy counterparts, a process that in itself seems to spur a normalization of memory-related activities in the brains of people with schizophrenia, suggests new research from Washington University in St. Louis.

Heavy drinking is associated with a number of problems, but one surprisingly common problem involves not remembering large chunks of time. Called alcohol-induced blackouts, these memory losses were reported by more than 39 percent of women and more than 50 percent of men studied by researchers from Washington University School of Medicine in St. Louis and the Queensland Institute on Medical Research in Australia. The researchers also found that genetic factors play a big role in whether or not a person blacks out after heavy drinking. Studying more than 2,300 pairs of Australian twins, the research team was able to determine that more than 50 percent of the risk of blacking out seems to be controlled by genetic factors, and the role of genes is even greater in people who report blacking out multiple times.

The mind and the body are intimately linked, but although more and more research is demonstrating that the mind plays a role in sickness and in health, little is understood about how a person’s mental health affects physical health. A Washington University team of investigators led by Ray E. Clouse, M.D, professor of medicine and psychiatry, and Patrick J. Lustman, Ph.D., professor of psychiatry, hopes to change that by launching a new Center for Mind/Body Research that will focus specifically on ways that mental health affects heart disease, diabetes, cancer and other illnesses. New research has shown, for example, that although women are at a lower risk for heart attacks than men, the risk for women with diabetes and depression is virtually identical to what’s seen in men. The investigators believe that depression is the main cause of that increased risk, but they hope that by focusing more closely on mind/body interactions they will be able to understand more about the relationship between mental health and physical well being.