Washington University’s Bear Cub program is funding four innovative projects that have commercial potential. Pictured is William G. Hawkins, MD, who is developing a new treatment for pancreatic cancer.
Nanostructures called BRIGHTs seek out biomarkers on cells and then beam brightly to reveal their locations. In the tiny gap between the gold skin and the gold core of the nanoparticle, there is an electromagnetic hot spot that lights up the reporter molecules trapped there. BRIGHTs, which shine about 1.7 x 1011 more brightly than isolated Raman reporters, are intended for use in noninvasive bioimaging.