Washington University opens clinic for treatment-resistant depression

Washington University School of Medicine has opened a clinic for patients with treatment-resistant depression that targets those who haven’t responded to standard therapies. When at least two therapies have been tried, and a patient still hasn’t responded, that patient is said to have treatment-resistant depression, according to clinic director Charles R. Conway, MD.  

Drug may prevent recurrence of depression in patients with diabetes

WUSM professor Patrick Lustman meets with a patient.A team of researchers at the School of Medicine has found that an antidepressant medication may reduce the risk of recurrent depression and increase the length of time between depressive episodes in patients with diabetes. Controlling depression in diabetes is important in helping patients manage their blood sugar. As depression improves, glucose levels also tend to improve.

Antidepressant drug may prevent recurrence of depression in patients with diabetes

Patrick Lustman meets with a patient.A team of researchers at Washington University School of Medicine in St. Louis has found that an antidepressant medication may reduce the risk of recurrent depression and increase the length of time between depressive episodes in patients with diabetes. Controlling depression in diabetes is important in helping patients manage their blood sugar. As depression improves, glucose levels also tend to improve. Although depression affects about 5 percent of the general population, the rate is about 25 percent for patients with diabetes. More…

Low receptor levels and low mood

Areas of red and yellow show increased uptake of the altanserin tracer due to binding to the serotonin receptors.Most of us feel sad from time to time, even very sad, but during a bout of clinical depression, a person is unable to escape their low mood for several weeks at a time. A popular and effective treatment for depression involves a class of drugs called selective serotonin reuptake inhibitors (SSRIs). Those drugs increase serotonin levels in the brain and help relieve symptoms of depression, and most scientists believe the brain chemical serotonin plays a key role in depression. Now neuroscience researchers at Washington University School of Medicine in St. Louis have found that in people who are depressed, a key brain structure has an abnormally low number of cellular serotonin receptors.