Using top-of-the-line research instrumentation from Agilent and Merck, scientists in the Department of Chemistry in Arts & Sciences will develop new metabolomics workflows of interest to many members of the drug-development community.
A new study with zebrafish shows that a deadly form of skin cancer — melanoma — alters the metabolism of healthy tissues elsewhere in the body. The research led by chemist Gary Patti suggests that these other tissues could potentially be targeted to help treat cancer.
Linda J. Pike and Alexander S. Holehouse, in the Department of Biochemistry and Molecular Biophysics at the School of Medicine, and Gary J. Patti, in Arts & Sciences and the School of Medicine, received a four-year grant totaling $1.45 million from the National Institute of General Medical Sciences of the National Institutes of Health (NIH).
Joseph A. Fournier, assistant professor of chemistry in Arts & Sciences, won a CAREER Award from the National Science Foundation. Fournier’s research program focuses on characterizing the dynamics and mechanisms of fast chemical reactions.
David Fike, professor of earth and planetary sciences and director of environmental studies, both in Arts & Sciences at Washington University in St. Louis, won a $98,406 EAGER Grant from the National Science Foundation for a project in geobiology and low-temperature geochemistry.
Macy Sprunger, a graduate student in Meredith Jackrel’s lab in the Department of Chemistry in Arts & Sciences at Washington University in St. Louis, won a three-year $136,560 National Research Service Award from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH). Such fellowships support predoctoral students conducting research in scientific health-related fields.
The fluorine isotope is the fifth new isotope that Robert J. Charity, research professor of chemistry in Arts & Sciences, and Lee G. Sobotka, professor of chemistry and of physics, have discovered together. They reported their observations in the journal Physical Review Letters.
New research from Washington University in St. Louis reveals the core structure of the light-harvesting antenna of cyanobacteria — including features that both collect energy and block excess light absorption. Orange carotenoid protein plays a key protective role, according to Haijun Liu, research scientist in chemistry in Arts & Sciences at Washington University in St. Louis.
By publishing their method in the journal Nature Protocols, chemists including Michael Gross, who has a joint appointment in Arts & Sciences and the School of Medicine, have opened doors for fellow scientists to better address research questions related to Alzheimer’s disease, the COVID-19 pandemic and more.
Meredith Jackrel, in Arts & Sciences, studies protein misfolding and how it leads to disease. She is collaborating with Jai Rudra at the McKelvey School of Engineering to develop amyloid-inspired vaccine technologies specifically tailored for seniors. The approach could be relevant to COVID-19 as the elderly are particularly susceptible to its severe complications.