aging

Resveratrol — found in red wine, grapes, blueberries, peanuts and other plants — stops out-of-control blood vessel growth in the eye, according to vision researchers at Washington University School of Medicine in St. Louis. The discovery has implications for preserving vision in blinding eye diseases such as diabetic retinopathy and age-related macular degeneration.

Researchers at Washington University School of Medicine in St. Louis are studying people age 60 and older to determine whether augmenting medication for depression with a second drug might help older patients break free of clinical depression. Both study drugs are FDA-approved therapies for depression in younger adults, but the benefits need to be examined in older adults. 

Organisms from yeast to rodents to humans all benefit from cutting calories. In less complex organisms, restricting calories can double or even triple lifespan. But researchers at Washington University School of Medicine and two other centers report in the journal Science that they are less interested in calorie restriction for longer life than for its ability to promote good health throughout life.  

The Longer Life Foundation has awarded grants to six research projects on issues related to aging at Washington University School of Medicine. Over the last 10 years, the foundation has awarded more than $2 million to the university to fund independent research into improving methods for predicting long-term mortality.

HIV infection or the treatments used to control it are prematurely aging the brain, researchers at Washington University School of Medicine in St. Louis and the University of California-San Diego have found. Blood flow in the brains of HIV patients is reduced to levels normally seen in uninfected patients 15 to 20 years older.

It’s no laughing matter that older adults have a tougher time understanding basic jokes than do younger adults. It’s partially due to a cognitive decline associated with age, according to Washington University in St. Louis researchers Wingyun Mak, a graduate student in psychology in Arts & Sciences, and Brian Carpenter, Ph.D., Washington University associate professor of psychology.

DXA scans of a male patient with osteoporosisAlthough women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating – or even life-threatening – fractures. In women, low estrogen levels after menopause have been considered an important risk factor for this disorder. Now research at the School of Medicine has shown that low amounts of active estrogen metabolites also can increase the the risk of osteoporosis in men.

DXA scans of a male patient with osteoporosisAlthough women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating – or even life-threatening – fractures. In women, low estrogen levels after menopause have been considered an important risk factor for this disorder. Now research at Washington University School of Medicine in St. Louis has shown that low amounts of active estrogen metabolites also can increase the the risk of osteoporosis in men.

The surge of baby boomers now entering their 60s means more drivers on the road who may be impaired by dementia or other cognitive impairments linked to aging. Researchers at the Alzheimer’s Disease Research Center (ADRC) at the School of Medicine and elsewhere have developed a three-hour workshop that trains health care providers to identify potentially unsafe drivers with dementia and to encourage appropriate retirement from driving.

The surge of baby boomers now entering their 60s means more drivers on the road who may be impaired by dementia or other cognitive impairments linked to aging. Researchers at the Alzheimer’s Disease Research Center (ADRC) of Washington University School of Medicine in St. Louis and elsewhere have developed a three-hour workshop that trains health care providers to identify potentially unsafe drivers with dementia and to encourage appropriate retirement from driving.