BRCA2

In a new analysis, researchers at the School of Medicine have shed light on the hereditary elements across 12 cancer types — showing a surprising inherited component to stomach cancer and providing some needed clarity on the consequences of certain types of mutations in well-known breast cancer susceptibility genes BRCA1 and BRCA2.

Repair proteins (bright green areas) are inhibited from gathering at sites of DNA damage.To remain healthy, all cells must quickly mend any breaks that arise in their DNA strands. But cancer cells are particularly dependent on a process called homologous recombination to repair DNA and stay alive. Now researchers at the School of Medicine have identified a protein with a role in homologous recombination, and the discovery could be exploited as part of a two-pronged treatment strategy to kill cancer cells by eliminating their ability to repair DNA.

Repair proteins (bright green areas) are inhibited from gathering at sites of DNA damage.To remain healthy, all cells must quickly mend any breaks that arise in their DNA strands. But cancer cells are particularly dependent on a process called homologous recombination to repair DNA and stay alive. Now researchers at Washington University School of Medicine in St. Louis have identified a protein with a role in homologous recombination, and the discovery could be exploited as part of a two-pronged treatment strategy to kill cancer cells by eliminating their ability to repair DNA.