fruit fly

A Washington University in St. Louis team is participating in the modENCODE project, a massive ongoing effort to map all the elements in model organisms that affect whether genes are silenced or expressed. The work supports the more complex ENCODE project, which is tasked to map the same elements in the human genome. While the genome is the same in every cell, each cell type expresses a different set of genes. In people, moreover, roughly 95 percent of the genome is silenced. Together the projects will “put flesh on the bones” of the Human Genome Project, says team leader Sarah C.R. Elgin.

<img src="/news/PublishingImages/4048_t.jpg" alt="Pretty fly — for a fruit fly. The areas stained blue are regions in the fruit fly where the spineless gene is expressed.” height=”211″ width=”150″ />Pretty fly – for a fruit fly. The areas stained blue are regions in the fruit fly where the spineless gene is expressed.A team of researchers that includes biologists from Washington University in St. Louis has discovered that a gene involved in the development and function of the fruit fly antenna also gives the organism its color vision. Claude Desplan, Ph.D., professor of biology at New York University, and his students made the discovery and provided the data. Ian Duncan, Washington University professor of biology, and his wife, research assistant Dianne Duncan, provided the Desplan laboratory fruit fly (Drosophila) clones and mutants and technical assistance that helped locate where the gene, called spineless, is expressed in the retina. More…

Drosophila melanoFor years, two schools of thought have dominated neurobiologists’ theories about how early nerve cells develop specialties that allow the assembly of a mature brain. One theory suggests master regulators trigger the development, while the other attributes the development to interactions between local factors. In a new study of developing fruit fly brain cells, scientists at Washington University School of Medicine and Harvard University showed that both models are valid.

Drosophila melanoFor years, two schools of thought have dominated neurobiologists’ theories about how early nerve cells develop specialties that allow the assembly of a mature brain. One theory suggests master regulators trigger the development, while the other attributes the development to interactions between local factors. In a new study of developing fruit fly brain cells, scientists at Washington University School of Medicine and Harvard University showed that both models are valid.