heart attack

Red areas of the circled leg in the right image show increased blood flow due to angiogenic cells.To speed healing at sites of injury – such as heart muscle after a heart attack or brain tissue after a stroke – doctors would like to be able to hasten the formation of new blood vessels. One promising approach is to “mobilize” patients’ blood vessel-forming cells, called angiogenic cells, so these cells can reach the injured area. Recently, researchers at Washington University School of Medicine in St. Louis demonstrated that a drug called AMD3100 can mobilize angiogenic cells from bone marrow of human patients in a matter of hours.

Abnormal heart rate variability increases the risk of death for depressed heart patients.Scientists have known for years that depression increases the risk of dying in the months after a heart attack, but they haven’t understood how depression raises that risk. Now, behavioral medicine specialists at the School of Medicine are reporting in the Archives of Internal Medicine that abnormal heart rate variability is partially responsible for depression’s effects in heart patients.

Abnormal heart rate variability increases the risk of death for depressed heart patients.Scientists have known for years that depression increases the risk of dying in the months after a heart attack, but they haven’t understood how depression raises that risk. Now, behavioral medicine specialists at Washington University School of Medicine in St. Louis are reporting in the Archives of Internal Medicine that abnormal heart rate variability is partially responsible for depression’s effects in heart patients.

The mind and the body are intimately linked, but although more and more research is demonstrating that the mind plays a role in sickness and in health, little is understood about how a person’s mental health affects physical health. A Washington University team of investigators led by Ray E. Clouse, M.D, professor of medicine and psychiatry, and Patrick J. Lustman, Ph.D., professor of psychiatry, hopes to change that by launching a new Center for Mind/Body Research that will focus specifically on ways that mental health affects heart disease, diabetes, cancer and other illnesses. New research has shown, for example, that although women are at a lower risk for heart attacks than men, the risk for women with diabetes and depression is virtually identical to what’s seen in men. The investigators believe that depression is the main cause of that increased risk, but they hope that by focusing more closely on mind/body interactions they will be able to understand more about the relationship between mental health and physical well being.

A team of researchers from Washington University School of Medicine in St. Louis, the Mayo Clinic in Rochester, Minn., the Harvard School of Public Health and several other clinical centers around the United States has found that treating depression and social isolation in recent heart attack patients does not reduce the risk of death or second heart attack. Results from the Enhancing Recovery in Coronary Heart Disease Patients Study (ENRICHD) are published in the June 18 issue of the Journal of the American Medical Association.