MRI scans

In school-age children previously diagnosed with depression as preschoolers, a key brain region involved in emotion is smaller than in their peers who were not depressed, scientists at the School of Medicine have shown.

Researchers at the School of Medicine have identified changes in the brains of children growing up in poverty. Those changes can lead to lifelong problems like depression, learning difficulties and limitations in the ability to cope with stress. But the study showed that the extent of those changes was influenced strongly by whether parents were attentive and nurturing. Pictured is principal investigator Joan L. Luby, MD.

Researchers have found significant differences in brain development in infants as young as six months old who later develop autism, compared to babies who don’t develop the disorder. The new research, which relied on brain scans acquired at night while infants were naturally sleeping, suggests that autism doesn’t appear abruptly, but instead develops over time during infancy.

Magnified nanoparticlesSpecially designed nanoparticles can reveal tiny cancerous tumors that are invisible to ordinary means of detection, according to a study by researchers at the School of Medicine. Researchers demonstrated that very small human melanoma tumors growing in mice — indiscernible from the surrounding tissue by direct MRI scan — could be “lit up” and easily located. Because the nanoparticles can be engineered to carry a variety of substances, they also may be able to deliver cancer-fighting drugs to malignant tumors.

Magnified nanoparticlesSpecially designed nanoparticles can reveal tiny cancerous tumors that are invisible to ordinary means of detection, according to a study by researchers at Washington University School of Medicine in St. Louis. Researchers demonstrated that very small human melanoma tumors growing in mice — indiscernible from the surrounding tissue by direct MRI scan — could be “lit up” and easily located. Because the nanoparticles can be engineered to carry a variety of substances, they also may be able to deliver cancer-fighting drugs to malignant tumors.